Artesunate restores the levels of inhibitory synapse proteins and reduces amyloid-β and C-terminal fragments (CTFs) of the amyloid precursor protein in an AD-mouse model

[[De...]]

 

Highlights

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Artesunate rescues gephyrin and GABAAR γ2 subunit expression in the hippocampus of a mouse AD-model.

 

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Artesunate reduces the formation of APP-CTFs.

 

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Low doses of artemisinin and artesunate reduce the number of amyloid plaques.

 

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In vitro nanomolar artesunate treatment of hAPPswe expressing hippocampal neurons reduces CTFs.

 

https://www.sciencedirect.com/science/article/abs/pii/S1044743121000373

 

https://pubmed.ncbi.nlm.nih.gov/33933588/

 

 

[[De...]]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236063/

 

*Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

 

Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate

https://www.mdpi.com/1422-0067/24/5/4623

 

Elucidating the molecular basis for inhibitory neurotransmission regulation by artemisinins

 

https://scholar.google.com.br/scholar?q=artesunate+gaba+a+receptors+expression&hl=pt-BR&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&t=1708628937664&u=%23p%3DN7eZ--VuJqIJ *

Need to read and understand in depts how It affects the gabaergic receptors and gabaergic signaling, given that It also inhibits Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission

 

https://www.pnas.org/doi/abs/10.1073/pnas.2008695117

 

This might play a role in restoring the inhibitory potential but might or might not cause anxiety, and maybe could be overcame by using something else 

 

Might help with neuropathy, but idk How It feels to take, usually i dont like glutamate antagonist, but It might bê diffrent with artesunate,

 

Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons

https://www.frontiersin.org/articles/10.3389/fnmol.2022.902572/full

 

 

Bridges between Antimalarials and Synaptic Transmission

 

https://www.sciencedirect.com/science/article/pii/S0896627319301060

 

 

 

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712024

 

 

Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27kip1 signaling pathway

 

https://www.aging-us.com/article/103121/text

 

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Here about the effects of gabaergic signaling on the immune system and T cells, reason of the auto-imune reactions mediated by withdrawals 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136847/

Edited February 22 by [De...]

[[De...]]

 

Artesunate Reduces Remifentanil-induced Hyperalgesia and Peroxiredoxin-3 Hyperacetylation via Modulating Spinal Metabotropic Glutamate Receptor 5 in Rats

https://www.sciencedirect.com/science/article/abs/pii/S0306452222000033

 

Dose dependant about Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958657/

Edited February 25 by [De...]

[[Na...]]

That’s all very interesting. Are you to the point of trialing it yourself?

I’ve wondered if impairment of the glycine receptor system might be mixed up in BIND, and it looks Artesunate might address that.  I wonder if Artemisinin would have the same effect. Less bioavailable but easier to get and less concerns with toxicity I think.

[[4M...]]

I started taking taking artemisinin about 2 years ago on and off. It doesn't do anything other than giving me sleep issues on days I take it.

[[De...]]

@[4M...] I guess its diffrent, similar but still diffrent, that goes for artemisin, arthemeter, artesunate, other analogues, @[Na...]yep im willing to try It in low doses , buying It from índia soon

 

https://www.hindawi.com/journals/jir/2022/9591544/

 

https://www.hindawi.com/journals/bmri/2016/1489050/

 

It explains more about its toxicity profile, between 1.75 mg/kg and 4mg/kg seems to be less toxic, dose dependant toxicity, its not liver friendly like niclosamide, so better keeping an eye doing tests

Edited March 7 by [De...]