Research on Garlic's Effect on Depression

[[Ro...]]

Study indicating garlic's anti-depressant-like effect:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792615/

[[Ja...]]

Hi rocknroll,

 

Do you take a peeled garlic daily? 

 

I started taking a peeled garlic starting today. I figured it couldn’t hurt.  My depression is really bad.

[[Ro...]]

Hi rocknroll,

 

Do you take a peeled garlic daily? 

 

I started taking a peeled garlic starting today. I figured it couldn’t hurt.  My depression is really bad.

 

I haven't tried one recently, but I think I just might do so.  At least it will keep the vampires away :-).

[[Ja...]]

Your so funny 😆

 

So the article with the findings on garlic helping mice with depression isn’t true? I skimmed through it but thought it was interesting.

 

I hate the garlic aftertaste.

[[Ro...]]

Your so funny 😆

 

So the article with the findings on garlic helping mice with depression isn’t true? I skimmed through it but thought it was interesting.

 

I hate the garlic aftertaste.

No, the article is true. I was just adding a little Halloween humor.

[[Ja...]]

ohhhhhhh, im super slow... and the klonopin made everything worse lol 

 

  I will continue taking my peeled garlic.  garlic breath it is .

 

thanks RR

[[Li...]]

For interested readers, here is the full title and abstract for this 2008 study conducted with Swiss albino mice.  Note the ‘doses’ of ethanolic extract used per kilogram.

 

Title

 

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice

 

Abstract

 

Objectives: The present study was undertaken to investigate the effect of the ethanolic extract of Allium sativum L. (Family: Lilliaceae), commonly known as garlic, on depression in mice.

 

Materials and methods: Ethanolic extract of garlic (25, 50 and 100 mg/kg) was administered orally for 14 successive days to young Swiss albino mice of either sex and antidepressant-like activity was evaluated employing tail suspension test (TST) and forced swim test (FST). The efficacy of the extract was compared with standard antidepressant drugs like fluoxetine and imipramine. The mechanism of action of the extract was investigated by co-administration of prazosin (alpha1-adrenoceptor antagonist), sulpiride (selective D2-receptor antagonist), baclofen (GABA(B) agonist) and p-CPA (serotonin antagonist) separately with the extract and by studying the effect of the extract on brain MAO-A and MAO-B levels.

 

Results: Garlic extract (25, 50 and 100 mg/kg) significantly decreased immobility time in a dose-dependent manner in both TST and FST, indicating significant antidepressant-like activity. The efficacy of the extract was found to be comparable to fluoxetine (20 mg/kg p.o.) and imipramine (15 mg/kg p.o.) in both TST and FST. The extract did not show any significant effect on the locomotor activity of the mice. Prazosin, sulpiride, baclofen and p-CPA significantly attenuated the extract-induced antidepressant-like effect in TST. Garlic extract (100 mg/kg) administered orally for 14 successive days significantly decreased brain MAO-A and MAO-B levels, as compared to the control group.

 

Conclusion: Garlic extract showed significant antidepressant-like activity probably by inhibiting MAO-A and MAO-B levels and through interaction with adrenergic, dopaminergic, serotonergic and GABAergic systems.

[[Ja...]]

Hi RR, and libertas,

 

I’ve been taking peeled organic garlic but how much do I have to take again for it to be effective?

[[Li...]]

Hello, Jacky boo.  Please bear in mind that:

 

(1) This study was conducted with Swiss albino mice. Results from animal studies do not always generalize to humans.

 

(2) The ‘treatment’ was an ethanol-based garlic extract not peeled garlic cloves. 

 

(3) The effects measured (decreased immobility time in the mice) were observed at a dose of 100mg of extract per 1 kilogram of weight.  One kilogram is about 2.2 pounds.  So a ‘mouse’ weighing 120 pounds would have been given about 5,455mg of the extract.

[[Ja...]]

Wow that’s a lot of garlic extract.  I’m going to continue my peeled garlic 🧄  because it helps with blood pressure and I’m sure other things and it won’t hurt.

 

Thank you for explaining things to me in a way I can understand.  I haven’t laughed all day until now, thank you for that.

 

♥️😘

 

[[el...]]

I am allergic to garlic unfortunately

[[Ja...]]

I had to stop garlic almost immediately because it was causing heart burn. When I stopped the heart burn never returned.

 

[[Ti...]]

It’s good for your heart too.

[[...]]

I read about the benefits of garlic here https://betterme.world/articles/eating-a-clove-of-garlic-before-bed/, though depression wasn't mentioned there. As far as I understood, you just need to eat a clove of garlic before bed and it is supposed to boost your immunity, treat insomnia, lower cholesterol, and help in weight loss. I haven't tried it myself, but maybe I should.