Significant Cellular Changes in Rat's Vital Organs After Only 4 Weeks on Benzos

[[pi...]]

Regarding the use of a specific rat, there are reasons for this in lab research.

 

https://en.m.wikipedia.org/wiki/Laboratory_rat

 

If you look under stocks and strains it explains why different kinds of albino rats are used particularly for medical research.

 

Terry and Becks, I find it disturbing as well.

I've known about this article for a year and have been through so much that I didn't have it in me to post, I was still afraid to post it. I know no one wants to see or hear this, I'm no fool. I'm well aware that many will want to skim over or outright reject this material.

 

I have gotten physically ill reading pinkyandthebrain's comment, so I'm not going to battle to explain why I feel this study is unbiased, objective and relevant, to those who have reactions like this.

I've already been through enough and I feel that psychiatric drugs were what led to what I've been through over the last year +. It's very personal to me, as it is to all of you, but I was one who did get very sick (in terms of mitochondrial damage to my cells which I believe led to further cell mutations. This is my story and I own the right to it, no would-be silencers can take it away from me.)

 

Hey Azalea

 

look sorry my comment elicited such a reaction. That really was not my intention at all, sincerely. I kinda went a bit for the tongue-in-cheek joke comment when I said "no take home messages except male albino rats being discriminated against". I thought it was obvious I dont seriously think male albino rates are being discriminated against. The no take home message part was to make it joking in tone, its a study of benzo's, of course i think theres more to take home then that

 

Also I kinda browse studies under the impression people supply studies for BB's to look at with the attitude "hey, have a look at this"......Not "this is my story" as you have indicated/extrapolated so I apologize if offence was given. Had I known you viewed this specific study as a validation or a reflection of your personal experience, I mean, of course I would not have taken a flippant tone or went to make a joke about the rats in the study.

 

I mean you and everyone on here well, I think humor helps in recovery so i take a light-hearted tone sometimes and am wary about overstepping given the emotional state of people in WD especially acute but I sincerely didn't think that comment would affect anyone especially as it was directed at the study and not at any individual (although if im trying to empathise, I can sort of see how it can look critical/dismissive in a way)

 

I also did some reading about why albino male rates are used, afterwards, which was interesting and of course see why its done now so your post of this study was quite interesting for that and many other reasons

 

Apologies again for how it affected you. If you want to know my actual serious opinion then......Im very intrigued by the results and I think there a lot of take away thoughts from this study and studies like this in terms of looking into the unknown of Benzo's affects on the mind and body. I have scanned through many studies relating to benzo's, this one was very unique and intriguing on many levels, also its very specific in so far as its going into the molecular level and beginning to trial the benzo distinctly on actual animal subjects and study the results much like a randomized controlled trail would do, in fact these studies are usually the precursors to the RCT's which are the gold standard we really need which would validate everything we are going through , which is always insightful and gives alot of hope,...great post, thankyou

 

I just thought Id start with a light hearted joke about rats being tested first, and then make a serious comment  . Will be more careful in future I guess

 

Hope the poor feelings didn't last too long and again I apologize and hope you can forgive/move past it as I honeslty didnt mean anything by it like newgirl suggested 

 

Wishing you well,

 

Pinky

[[az...]]

Becks, just woke up and enjoyed your comment. I'm intrigued right along with you guys and it's interesting fun to learn about your ties to medical science. Becks I would have more to say but I think I'll have coffee first. Very interesting- I just want to find more information too!

 

Pinky, I'm so sorry too. Your first comment is really cute (and I so much appreciate your second) and I totally missed it because of everything that's stored up in me- I do appreciate humor *most always* and this shows that this whole experience got the better of me once more, please forgive me. I'm glad you did it and now I think it's even funnier that I took it seriously or could not tell for some reason. There are absolutely no hard feelings and I now think it's hilarious. I like your signature, too, and the description of month 2. I'm sorry for all you have been through with the cold turkey, yikes.

 

Pinky, I now want to stalk all your other replies so that I can smile or laugh some more.

 

I'll write back again later

[[az...]]

Pinky, as I read your posts, I am confronted with your suffering (the kind that I am quite familiar with too.) I really hope I haven't caused you more pain. My heart breaks for all of us and I hope you are not too careful with your humor in the future- it is the right kind of healthy medicine.

❤️ 🐭 ❤️

 

Let us keep on keeping on 🐌

Slow and steady.

 

 

[[Be...]]

I also noticed in that study that the benzo's affect the aorta which comes out of the left side of the heart and runs down the middle of the body--the abdominal aorta--and a bit to the left of the midline. If you check an anatomy drawing, it shows that. That might explain why so many people in benzo w/d have left-sided pain and weakness?  I know my left side was very messed up when I got off the pills and is still a mess today.  The aorta and arteries and even veins, if they get damaged, can cause serious health problems, IMO.  I was diagnosed with Paroxysmal Tachycardia by the doc years ago.  He told me to stand up and then immediately checked my heart with his stethoscope and heard something irregular.  I know my BP was really messed up when I got off the pills.  I have alot of left-sided chest tightness and sometimes pain.  If our DNA gets damaged, I believe that can be bad news.  I think there is alot of helpful information in that research article.  I'm almost certain the study wasn't done here in the US.  I don't see any indication of that.  Overseas research tends to be less biased, I think.  I wish someone who knew alot about this stuff could read the article and then comment on it.     

[[az...]]

Becks, looks like Egypt:

 

Article information

Interdiscip Toxicol. 2011 Sep; 4(3): 132–143.

Published online 2011 Sep. doi:  10.2478/v10102-011-0021-y

PMCID: PMC3203915

Ghada E. Elmesallamy,1 Marwa A. Abass,1 Nahla A.G. Ahmed Refat,2 and Amal H. Atta3

1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Egypt

2Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Egypt

3Department of Microbiology, Faculty of Medicine, Zagazig University, Egypt

Correspondence address: Assist. Prof. Ghada Elsaid Ahmed Elmesallamy, MD. Assistant Professor of Clinical Toxicology, Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Egypt. TEL.: +20552302809, E-MAIL: moc.liamtoh@0142annag

Received 2011 Feb 20; Revised 2011 Jul 1; Accepted 2011 Jul 21.

Copyright © 2011 Slovak Toxicology Society SETOX

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article has been cited by other articles in PMC.)

Articles from Interdisciplinary Toxicology are provided here courtesy of Slovak Toxicology Society SETOX & Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences

 

(I am about to look up the other articles that cited this one.)

[[az...]]

Ok well, it's only one- an article on rats and stress.

 

 

[[az...]]

Looking through some of the articles they cited now.

 

Pancytopenia associated with clonazepam

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915945/?report=reader

 

Genotoxicity and carcinogenicity studies of benzodiazepines

http://www.sciencedirect.com/science/article/pii/S1043661807001582?via%3Dihub

 

Suppressive effects of alprazolam on the immune response of mice.

https://www.ncbi.nlm.nih.gov/m/pubmed/2071299/

 

Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387833/?report=reader

 

Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.

https://www.ncbi.nlm.nih.gov/m/pubmed/9653667/

 

Identification of a 17-kDa protein associated with the peripheral-type benzodiazepine receptor in vascular and other smooth muscle types.

https://www.ncbi.nlm.nih.gov/m/pubmed/1650838/

 

Effects of different doses and schedules of diazepam treatment on lymphocyte parameters in rats.

https://www.ncbi.nlm.nih.gov/m/pubmed/20846531/

 

Cytogenetic activity of newly synthesized 1,5-benzodiazepines in normal human lymphocyte cultures.

https://www.ncbi.nlm.nih.gov/m/pubmed/20373848/

 

Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice.

https://www.ncbi.nlm.nih.gov/m/pubmed/1649692/

 

Enigma of the peripheral benzodiazepine receptor.

https://www.ncbi.nlm.nih.gov/m/pubmed/10581326/

 

Genetic toxicology of four commonly used benzodiazepines: a review.

https://www.ncbi.nlm.nih.gov/m/pubmed/8692185/

 

Diazepam leads to enhanced severity of orthopoxvirus infection and immune suppression.

https://www.ncbi.nlm.nih.gov/m/pubmed/20659521/

 

Immunomodulating effects of tofizopam (Grandaxin) and diazepam in vitro.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781640/

 

Calcium channel blockers, apoptosis and cancer: is there a biologic relationship?

https://www.ncbi.nlm.nih.gov/m/pubmed/10588195/

 

Effects of midazolam on equine innate immune response: a flow cytometric study.

https://www.ncbi.nlm.nih.gov/m/pubmed/12969632/

 

Effects of diazepam on Mycobacterium bovis-induced infection in hamsters.

https://www.ncbi.nlm.nih.gov/m/pubmed/10464392/

 

Alprazolam intercalates into DNA.

https://www.ncbi.nlm.nih.gov/m/pubmed/19108581/

 

Prenatal diazepam induced persisting depression of cellular immune responses.

https://www.ncbi.nlm.nih.gov/m/pubmed/2538699/

 

Impaired host resistance to Trichinella spiralis as a consequence of prenatal treatment of rats with diazepam.

https://www.ncbi.nlm.nih.gov/m/pubmed/7801325/

 

The effect of chronic diazepam administration on lipid peroxidation and Ca2+ -ATPase activity in rat liver.

https://www.ncbi.nlm.nih.gov/m/pubmed/18277470/

 

Benzodiazepine receptor agonists modulate thymocyte apoptosis through reduction of the mitochondrial transmembrane potential.

https://www.ncbi.nlm.nih.gov/m/pubmed/10202853/

 

 

Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane.

https://www.ncbi.nlm.nih.gov/m/pubmed/11145616/

 

 

 

 

 

 

 

 

The list goes on...

[[ne...]]

Oh wow, so many studies! It must have been taken you a while to compile the list. Many thanks, azalea!

[[az...]]

❤️

[[az...]]

Now we just need a glossary...

 

The Free Medical Dictionary:

 

https://medical-dictionary.thefreedictionary.com

[[ne...]]

Hahahaha, you're funny!

[[Be...]]

We'd never find these types of studies here in the US.  I need an expert to explain all this to me.   

[[ba...]]

Looking through some of the articles they sited now.

 

Pancytopenia associated with clonazepam

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915945/?report=reader

 

Genotoxicity and carcinogenicity studies of benzodiazepines

http://www.sciencedirect.com/science/article/pii/S1043661807001582?via%3Dihub

 

Suppressive effects of alprazolam on the immune response of mice.

https://www.ncbi.nlm.nih.gov/m/pubmed/2071299/

 

Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387833/?report=reader

 

Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.

https://www.ncbi.nlm.nih.gov/m/pubmed/9653667/

 

Identification of a 17-kDa protein associated with the peripheral-type benzodiazepine receptor in vascular and other smooth muscle types.

https://www.ncbi.nlm.nih.gov/m/pubmed/1650838/

 

Effects of different doses and schedules of diazepam treatment on lymphocyte parameters in rats.

https://www.ncbi.nlm.nih.gov/m/pubmed/20846531/

 

Cytogenetic activity of newly synthesized 1,5-benzodiazepines in normal human lymphocyte cultures.

https://www.ncbi.nlm.nih.gov/m/pubmed/20373848/

 

Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice.

https://www.ncbi.nlm.nih.gov/m/pubmed/1649692/

 

Enigma of the peripheral benzodiazepine receptor.

https://www.ncbi.nlm.nih.gov/m/pubmed/10581326/

 

Genetic toxicology of four commonly used benzodiazepines: a review.

https://www.ncbi.nlm.nih.gov/m/pubmed/8692185/

 

Diazepam leads to enhanced severity of orthopoxvirus infection and immune suppression.

https://www.ncbi.nlm.nih.gov/m/pubmed/20659521/

 

Immunomodulating effects of tofizopam (Grandaxin) and diazepam in vitro.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781640/

 

Calcium channel blockers, apoptosis and cancer: is there a biologic relationship?

https://www.ncbi.nlm.nih.gov/m/pubmed/10588195/

 

Effects of midazolam on equine innate immune response: a flow cytometric study.

https://www.ncbi.nlm.nih.gov/m/pubmed/12969632/

 

Effects of diazepam on Mycobacterium bovis-induced infection in hamsters.

https://www.ncbi.nlm.nih.gov/m/pubmed/10464392/

 

Alprazolam intercalates into DNA.

https://www.ncbi.nlm.nih.gov/m/pubmed/19108581/

 

Prenatal diazepam induced persisting depression of cellular immune responses.

https://www.ncbi.nlm.nih.gov/m/pubmed/2538699/

 

Impaired host resistance to Trichinella spiralis as a consequence of prenatal treatment of rats with diazepam.

https://www.ncbi.nlm.nih.gov/m/pubmed/7801325/

 

The effect of chronic diazepam administration on lipid peroxidation and Ca2+ -ATPase activity in rat liver.

https://www.ncbi.nlm.nih.gov/m/pubmed/18277470/

 

Benzodiazepine receptor agonists modulate thymocyte apoptosis through reduction of the mitochondrial transmembrane potential.

https://www.ncbi.nlm.nih.gov/m/pubmed/10202853/

 

 

Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane.

https://www.ncbi.nlm.nih.gov/m/pubmed/11145616/

 

 

 

 

 

 

 

 

The list goes on...

 

Great list azalea,

 

So you think they do know?

 

 

Nah

[[az...]]

Not only Taiwan, but in Denmark:

 

Use of benzodiazepines or benzodiazepine related drugs and the risk of cancer: a population-based case-control study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635606/#!po=21.1111

[[az...]]

I'm skimming, but I believe we have scientific medical research citations previously listed to support the hypothesis that certain benzodiazepines are not only tumor promoters (as this article from 1981 suggests) but also tumor initiators [example: "Alprazolam intercalates (inserts) into DNA".]

 

The Possible Effect of Diazepam on Cancer Development and Growth

https://www.benzo.org.uk/amisc/horrobin1981.pdf

 

 

The articles are out there, sometimes it requires digging and looking up words.

 

[[ne...]]

I think they DO know. At leat Big Pharma does.

[[az...]]

Truly, babyrex.

 

How many studies do "they" need?

 

As per the words of the second study I listed in the first long list (as I mentioned to you I saw that when one clicks on one of those they will find more similar articles of studies listed beneath) titled "Genotoxicity and carcinogenicity studies of benzodiazepines" through the Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology at the University of Genoa in Genoa, Italy,  they had tested "Only 8 (19.5%) of the 41 marketed benzodiazepines and benzodiazepine analogues had all data required by current guidelines for testing of pharmaceuticals" by 2007.

 

[[az...]]

International Journal of Cancer

 

 

View  issue TOC

Volume 140, Issue 3

1 February 2017

Pages 513–525

Cancer Epidemiology

Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies

Authors

Hong-Bae Kim,

Seung-Kwon Myung,

Yon Chul Park,

Byoungjin Park

First published:

5 October 2016Full publication history

DOI:

10.1002/ijc.30443  View/save citation

Cited by (CrossRef):

0 articles Check for updates Citation tools

Article has an altmetric score of 3

This article was published online on 5 October 2016. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 12 October 2016.

Abstract

 

Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publications in January 2016. Three evaluators independently reviewed and selected eligible studies based on predetermined selection criteria. Of 796 articles meeting our initial criteria, a total of 22 observational epidemiological studies with 18 case-control studies and 4 cohort studies were included in the final analysis. Benzodiazepine use was significantly associated with an increased risk of cancer (odds ratio [OR] or relative risk [RR] 1.19; 95% confidence interval 1.16–1.21) in a random-effects meta-analysis of all studies. Subgroup meta-analyses by various factors such as study design, type of case-control study, study region, and methodological quality of study showed consistent findings. Also, a significant dose-response relationship was observed between the use of benzodiazepine and the risk of cancer (p for trend <0.01). The current meta-analysis of observational epidemiological studies suggests that benzodiazepine use is associated with an increased risk of cancer.

[[az...]]

Also, I have rigorously looked into the definition of the word "news" and everything I've posted does fit. Scientific articles and medical journals count, and also the Taiwan population study was covered by CNN and other popular and also more "alternative" (such as Mad in America) news outlets.

 

Benzos and cancer are in the major news outlet corporations on a nearly microscopic scale compared to medical periodicals, but they are there. I saw this a year ago but the only scholarly articles I could find were the first two I shared and my doctors were not interested and I had to go through chemo and just do that at the time.

 

But anyway, my point being that Merriam Webster, etc.'s definitions for news, all cover medical and scientific articles and periodicals in their definition of the term.

 

I can prove this with links and copy/paste, or anyone can look it up. I liked this link http://libanswers.umflint.edu/faq/86816

 

So the crux of the matter is that news isn't just the network corporations we are all familiar with in our countries (especially America for me and other US citizens) but that news is more than just these.

[[az...]]

I think they DO know. At leat Big Pharma does.

 

Me too. I also think they throw studies out there with the aim to contradict the studies done by unbiased research... among many other things (as we are pretty much all aware by now.)

 

My main concern at present is why I was not able to find these a year ago, apart from the first two, and then why when I just went back on google and put in "benzodiazepines research cancer" just now, the order of the articles had changed and the more relevant ones are now harder to find and further back or I am not seeing them at all yet. Perhaps I won't be clearing my cache as often, couldn't that have something to do with it?

 

edit: ok so what I did was go back through this post and click all the links again and close those windows out and then put the search terms in and the results do look the same as they had yesterday (for now.) Search after clicking through all the links on the post and entering the search terms in the quotes in the previous paragraph right here and you should see what I'm seeing- seemingly endless applicable articles to the topic at hand with supportive evidence. Bookmark (for yourself) or post any new articles you can or want to which haven't previously been posted. Not that we don't have enough to work with for now on this thread, but this is the best way I've found to access these articles and it might be wise to save them for oneself (at least) if one has personal interest.

[Guest [ch...]]

It's not clear what it means to say a big company "knows" something. Obviously there are people who work for big pharma that know their products are dangerous. Just like there are people who work for big oil that know their product causes climate change which will doom civilization. However, companies exist to make money for their stockholders, and the company's position will be to deny harm and to promote their products. Companies are good at manipulating peoples perception of the truth. Look at how many people believe climate change doesn't even exist - a result of huge number of $$ spent by big oil. Human knowledge is socially constructed, and companies exploit that to the utmost.

 

[[az...]]

It's not clear what it means to say a big company "knows" something. Obviously there are people who work for big pharma that know their products are dangerous. Just like there are people who work for big oil that know their product causes climate change which will doom civilization. However, companies exist to make money for their stockholders, and the company's position will be to deny harm and to promote their products. Companies are good at manipulating peoples perception of the truth. Look at how many people believe climate change doesn't even exist - a result of huge number of $$ spent by big oil. Human knowledge is socially constructed, and companies exploit that to the utmost.

 

I agree totally.

[[az...]]

chessplayer, I was thinking more of the FDA- but all one needs to do in order to learn about that mess and how the heads of those companies (the drug companies) serve on the board there is start with "American Addict" on Netflix.

 

Apparently the same individuals simply change hats and filter back and forth between the two.

[[ne...]]

Shocking! 

[[Bu...]]

Great research Azaelea-very eye opening   Thank you for posting these.