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Klonopin & Valium.


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Do you find this statement to be true?

 

Further Note on Klonopin vs Valium: April 15, 2002. It is well known that Klonopin is a good anticonvulsant. In fact its only indication for use in the UK is for epilepsy. The fact that it has a higher affinity for GABA-A receptor sites than diazepam simply means that it is more potent, but potency is mainly a matter of equivalent dosages. Binding of clonazepam to receptors that do not bind to other benzodiazepines and action on sodium channel conductors are relevant to anticonvulsant effects, not tranquillising effects. The fact that clonazepam has sedative and anxiolytic actions and typical adverse effects of benzodiazepines including ataxia, irritability, depression and tolerance shows that there is little overall difference.

 

Since clonazepam has a relatively short half life, from 18 to 50 hours, I don't think it would be any easier to come off it using 1/64th mg capsules. I think you still need a long-acting benzodiazepine such as diazepam. I would also reiterate that I have known people make the clonazepam to diazepam substitution and final withdrawal without difficulty.

 

Thanks.

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Do you find this statement to be true?

 

Further Note on Klonopin vs Valium: April 15, 2002. It is well known that Klonopin is a good anticonvulsant. In fact its only indication for use in the UK is for epilepsy. The fact that it has a higher affinity for GABA-A receptor sites than diazepam simply means that it is more potent, but potency is mainly a matter of equivalent dosages. Binding of clonazepam to receptors that do not bind to other benzodiazepines and action on sodium channel conductors are relevant to anticonvulsant effects, not tranquillising effects. The fact that clonazepam has sedative and anxiolytic actions and typical adverse effects of benzodiazepines including ataxia, irritability, depression and tolerance shows that there is little overall difference.

 

Since clonazepam has a relatively short half life, from 18 to 50 hours, I don't think it would be any easier to come off it using 1/64th mg capsules. I think you still need a long-acting benzodiazepine such as diazepam. I would also reiterate that I have known people make the clonazepam to diazepam substitution and final withdrawal without difficulty.

 

Thanks.

 

Thank you sigma for everything

the advise

mishi

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