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Post-withdrawal nervous system hypersensitivity, hyper-reactivity and kindling


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I've taken this from https://www.survivingantidepressants.org/topic/8095-post-withdrawal-nervous-system-hypersensitivity-hyper-reactivity-and-kindling/?tab=comments#comment-4053, just thought I'd share it as see a lot of discussion about the sensitizes nervous system and kindling



"Going on and off drugs and taking doses inconsistently can cause nervous system destabilization and hypersensitivity. This predispose someone to kindling, an adverse reaction when increasing the dosage or taking another drug, even a drug that caused no problems before.




The hypersensitivity common in nervous system destabiization underlies kindling.




W-BAD World Benzodizapine Awareness Day. (2020). Kindling. World Benzodiazapine Awareness Day July 11. https://w-bad.org/kindling/


Wikipedia. (2020). Kindling (sedative–hypnotic withdrawal). In Wikipedia. https://en.wikipedia.org/w/index.php?title=Kindling_(sedative-hypnotic_withdrawal)&oldid=966037191



Kaymaz, N., van Os, J., Loonen, A. J. M., & Nolan, W. A. (2008). Evidence That Patients With Single Versus Recurrent Depressive Episodes Are Differentially Sensitive to Treatment Discontinuation: A Meta-Analysis of Placebo-Controlled Randomized Trials. The Journal of Clinical Psychiatry, 69(9), 1423–1436. https://doi.org/10.4088/JCP.v69n0910




Allison, C., & Pratt, J. A. (2003). Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence. Pharmacology & Therapeutics, 98(2), 171–195. https://doi.org/10.1016/S0163-7258(03)00029-9




Kraus, J. E. (2000). Sensitization Phenomena in Psychiatric Illness: Lessons from the Kindling Model. The Journal of Neuropsychiatry and Clinical Neurosciences, 12(3), 328–343. https://doi.org/10.1176/jnp.12.3.328




Bell, I. R., Rossi, J., Gilbert, M. E., Kobal, G., Morrow, L. A., Newlin, D. B., Sorg, B. A., & Wood, R. W. (1997). Testing the neural sensitization and kindling hypothesis for illness from low levels of environmental chemicals. Environmental Health Perspectives, 105(suppl 2), 539–547. https://doi.org/10.1289/ehp.97105s2539




Fava, G. A. (1995). Holding on: Depression, sensitization by antidepressant drugs, and the prodigal experts. Psychotherapy and Psychosomatics, 64(2), 57–61. https://doi.org/10.1159/000288992"



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