Jump to content
Important Survey - Please Participate ×

Study, Nov./16: CYP450 enzymes (genetic variants) affect fall risk w/benzos


[La...]

Recommended Posts

The full title of this Dutch/American study is "CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis".

 

It's quite fascinating to see a study that looks at a specific genetic variants and a particular side effect of taking benzodiazepines.  For those of us who are dizzy, "increased fall risk" can be translated as "having poor balance or decreased stability", which makes this study of particular interest to us. It may explain why some of us are more dizzy than others.

 

From the Results:

 

"Within benzodiazepine users, having a CYP2C9*2 or *3 allele was associated with an increased fall risk (HR, 1.35; 95% CI, 1.06; 1.72). Additionally, we observed an allele dose effect; heterozygous allele carriers had a fall risk of (HR = 1.30; 95% CI, 1.05; 1.61), and homozygous allele carriers of (HR = 1.91 95% CI, 1.23; 2.96)."

 

"CONCLUSIONS:  CYP2C9*2 and *3 allele variants modify benzodiazepine-related fall risk. Those using benzodiazepines and having reduced CYP2C9 enzyme activity based on their genotype are at increased fall risk. In clinical practice, genotyping might be considered for elderly patients with an indication for benzodiazepine use. However, because the exact role of CYP2C9 in benzodiazepine metabolism is still unclear, additional research is warranted."

 

https://www.ncbi.nlm.nih.gov/pubmed/27889507 

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...