how long benzos stay in system thats why were sick

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How long do benzodiazepines stay in the body after withdrawal? This question is often asked by people with long-term symptoms. Is it possible that one cause of protracted symptoms is that benzodiazepines remain in the body even after months, lurking perhaps deep in such tissues as brain and bones? Could slow elimination from these sites keep the withdrawal symptoms going?

 

Like many other issues concerning benzodiazepines, the answers to these questions are still unclear. Benzodiazepine concentrations in the blood have been measured and shown to reach undetectable levels in 3-4 weeks after cessation of use in people withdrawn from clinical doses. Information on benzodiazepine concentrations in the brain and other tissues is difficult to obtain, especially in humans. Benzodiazepines certainly enter the brain and also dissolve in all fatty (lipid-containing) tissues including fat deposits all over the body. It is possible that they linger in such tissues for some time after blood levels have become undetectable. However, most body tissues are in equilibrium with the blood that constantly perfuses them, and there is no known mechanism whereby benzodiazepines could be "locked up" in tissues such as the brain. There is no data on how long benzodiazepines remain in bones, which have a lower fat content but also a slower rate of cell turnover.

 

Nevertheless, the concentration of benzodiazepines remaining in body tissues after withdrawal must be very low, otherwise the drugs would leak back into the blood in discernible amounts. It is difficult to imagine that such concentrations would be sufficient to produce clinical effects or that any direct effects could last for months or years. However, it is not inconceivable that even low concentrations might be enough to prevent the return of GABA/benzodiazepine receptors in the brain to their pre-benzodiazepine state. If so, the receptors would continue to be resistant to the natural calming actions of GABA (See Chapter I), and the effect could be to prolong the state of nervous system hyperexcitability. Possible factors contributing to protracted symptoms

[Guest [...]]

Oh no! A thought just went through my head. It has lurked before reading this. If benzos are fat soluble and lurk in  the fat tissue long after their supply is cut off, does it mean that the more fat cells you have, because you are overweight, the longer it will take to eradicate the mongrel things?

 

Please tell me that benzos are not so discriminatory against we people who have let ourselves run to seed! So not fair!

 

Xana

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I was thinking about the brain it is all fat. so how do you detox the brain.

[[Te...]]

raypach, marijuana does attach to brain cells but you have trillions & trillions of those little suckers and I really don't believe smoking medical marijuana, one time a week x 6 months did any permanent damage.  With what you have posted....I was most concerned that you went c/t  on the Klonopin.  I don't think the marijuana is the culprit in your case, just my opinion and sorry, I certainly don't have a solution for you either. 

 

Taz

 

 

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the article was about benzos it said benzos are fat soluble

[[el...]]

Benzos will not partition into and remain in fatty tissues in the body. They have very low octanol-water partition coefficients (which are essentially ratios of concentrations in fat to concentrations in water). They will perfuse into blood, metabolize, and be excreted fairly rapidly. They won’t hang around in fatty tissue like some other organic compounds that have extremely high partition coefficients (i.e., PCBs, some chlorinated pesticides and herbicides, and others). Benzos simply do their damage and leave - leaving a mess for our brains to repair.

 

[[ra...]]

I hot this info from the Ashton Manual    http://www.benzo.org.uk/manual/bzcha03.htm#t4

[[el...]]

I think Dr. Ashton was basically “thinking out loud” on the subject of how long benzos might remain in the body. Given the solubility/partition coefficient data for benzos, it can be shown that benzos are completely gone from the body within probably a few weeks after the last dose. When I was employed as a scientist, I did computer modeling of the fate of chemical compounds  based on their physical and chemical properties. I had models that would demonstrate that benzos would be depleted fairly quickly from a human body. Sadly, benzos brought me down and I had to retire last year (after 30 years). But, my benzo brain is healing and “it’s all coming back to me” again.

[[ba...]]

You need to read Bliss johns book Benzo wise