Study, Apr/19: Challenges of Post-Traumatic Stress Disorder: Focus on dopamine

[[La...]]

The full title of this Italian study is "Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System".

 

https://www.ncbi.nlm.nih.gov/pubmed/31057408

 

Abstract

 

Post-traumatic stress disorder (PTSD) is a mental illness developed by vulnerable individuals exposed to life-threatening events. The pharmacological unresponsiveness displayed by the vast majority of PTSD patients has raised considerable interest in understanding the poorly known pathophysiological mechanisms underlying this disorder. Most studies in the field focused, so far, on noradrenergic mechanisms, because of their well-established role in either tuning arousal or in encoding emotional memories. However, less attention has been paid to other neural systems. Manipulations of the dopaminergic system alter behavioral responses to stressful situations and recent findings suggest that dopaminergic dysfunction might play an overriding role in the pathophysiology of PTSD. In the present review, dopaminergic mechanisms relevant for the pathogenesis of PTSD, as well as potential dopaminergic-based pharmacotherapies are discussed in the context of addressing the unmet medical need for new and effective drugs for treatment of PTSD.

 

 

[[cs...]]

Thanks for post this

 

“Growing evidence indicates that a failure of the top-down inhibitory control exerted by the medial prefrontal cortex (mPFC) over the limbic regions and especially over the amygdala is responsible for these intrusion symptoms (Figure 1; Lanius et al., 2010). Particularly, the impairment of cortical inhibitory control seems to be intimately related to a disrupted fear extinction (Milad et al., 2009), which contributes to exaggerated fear associated with the recurrence of traumatic memories.”

[[co...]]

THE BRAIN THE BRAIN THE BRAIN

 

How about the circumstances of people's lives?  Maybe "they" should start there???

[[Ma...]]

Post-traumatic stress disorder (PTSD) is a mental illness developed by vulnerable individuals exposed to life-threatening events.

 

That makes me mad! EVERY Human can develop a PTSD. Trauma doesn't chose the weak ones.

Everyone is vulnerable.

 

Is that my poor English - or do I understand this sentence wrong, Lapis?

[[La...]]

I think, Marigold, that they have a lot of trouble describing what we commonly refer to as "mental illness". They keep looking for "pathophysiological" reasons when it may just be that we can't explain things using such reasoning.

 

Anyway, I think you're completely right. PTSD can hit anyone, depending on the circumstances.

 

They're going to keep looking for magic pills, though. I think that's what this particular study is saying. I was going to note that when I posted it, but I didn't. It's the same with depression. They still haven't found the biological marker for depression, and they just keep handing out the pills, whether or not they work. 

 

 

[[Ma...]]

I think, Marigold, that they have a lot of trouble describing what we commonly refer to as "mental illness". They keep looking for "pathophysiological" reasons when it may just be that we can't explain things using such reasoning.

 

Anyway, I think you're completely right. PTSD can hit anyone, depending on the circumstances.

 

They're going to keep looking for magic pills, though. I think that's what this particular study is saying. I was going to note that when I posted it, but I didn't. It's the same with depression. They still haven't found the biological marker for depression, and they just keep handing out the pills, whether or not they work.

 

You know I have overcome a real trauma with PTBS and the hypothetical idea that only the people get hurt who are vulnerable or born victims - that is quiet common. I am always shocked that they tell this to people who were abused or survived horrible situations like torture - it just shows how un-natural the doctors behave and that they judge instead of support. And in the end - a pill is needed.

 

[[La...]]

I think, Marigold, that they have a lot of trouble describing what we commonly refer to as "mental illness". They keep looking for "pathophysiological" reasons when it may just be that we can't explain things using such reasoning.

 

Anyway, I think you're completely right. PTSD can hit anyone, depending on the circumstances.

 

They're going to keep looking for magic pills, though. I think that's what this particular study is saying. I was going to note that when I posted it, but I didn't. It's the same with depression. They still haven't found the biological marker for depression, and they just keep handing out the pills, whether or not they work.

 

You know I have overcome a real trauma with PTBS and the hypothetical idea that only the people get hurt who are vulnerable or born victims - that is quiet common. I am always shocked that they tell this to people who were abused or survived horrible situations like torture - it just shows how un-natural the doctors behave and that they judge instead of support. And in the end - a pill is needed.

 

I've been meaning to ask you, Marigold...What does PTBS stand for? Is it a European or German term for what we in North America call Post-Traumatic Stress Disorder, or PTSD? I'm guessing so, but I haven't come across that term before.

 

PTSD is a term that has replaced "Shell Shock" (World War I) and "Combat Stress Reaction" (World War II), I've just learned (from the Wikipedia entry). They can't logically say that soldiers who had shell shock, combat stress reaction or PTSD were "vulnerable" while the other soldiers weren't. All human beings are vulnerable to such things, as long as they're human beings.

[[Ma...]]

I think, Marigold, that they have a lot of trouble describing what we commonly refer to as "mental illness". They keep looking for "pathophysiological" reasons when it may just be that we can't explain things using such reasoning.

 

Anyway, I think you're completely right. PTSD can hit anyone, depending on the circumstances.

 

They're going to keep looking for magic pills, though. I think that's what this particular study is saying. I was going to note that when I posted it, but I didn't. It's the same with depression. They still haven't found the biological marker for depression, and they just keep handing out the pills, whether or not they work.

 

You know I have overcome a real trauma with PTBS and the hypothetical idea that only the people get hurt who are vulnerable or born victims - that is quiet common. I am always shocked that they tell this to people who were abused or survived horrible situations like torture - it just shows how un-natural the doctors behave and that they judge instead of support. And in the end - a pill is needed.

 

I've been meaning to ask you, Marigold...What does PTBS stand for? Is it a European or German term for what we in North America call Post-Traumatic Stress Disorder, or PTSD? I'm guessing so, but I haven't come across that term before.

 

PTSD is a term that has replaced "Shell Shock" (World War I) and "Combat Stress Reaction" (World War II), I've just learned (from the Wikipedia entry). They can't logically say that soldiers who had shell shock, combat stress reaction or PTSD were "vulnerable" while the other soldiers weren't. All human beings are vulnerable to such things, as long as they're human beings.

 

Oh yes, totally right. In English its PTSD and in German PTBS. Its the same thing. I was diagnosed with that some years ago (correct diagnosis) and met a lot of veterans in my therapy. My experience is more the opposite - people who deal with a PTSD are the strong ones, fighting for others, the survivors - and the fact they are still alive is a proof for their strength and not that they are vulnerable.

I remember some doctors forcing me to tell them details. In the end I shared some. One threw up, another one cried. Very unprofessional. So who is vulnerable. Ugh.

I am happy I am a survivor and able to enjoy life again. I would not have needed the med disaster, but well