Case Report, Apr/19: Serotonin Syndrome w/SSRI monotherapy (only one type)

[[La...]]

The full title of this American case report is "A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy".

 

https://www.ncbi.nlm.nih.gov/pubmed/31030620

 

Abstract

 

INTRODUCTION:

 

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) with several indications, one of which is for depression. We present a case of probable paroxetine-induced serotonin syndrome.

 

CASE SUMMARY:

 

A 21-year-old female with a history of generalized anxiety disorder and major depression presented with increased depressive symptoms over several months while taking fluoxetine 20 mg daily. Fluoxetine was discontinued without taper and replaced with paroxetine 10 mg daily, along with hydroxyzine 50 mg twice daily as needed for anxiety. Within a week of starting the paroxetine, the patient reported increased anxiety, insomnia, and constant shaking. The paroxetine continued to be uptitrated over a 3-week period to a dose 30 mg due to unremitting depressive symptoms. One month later, the patient presented with tachycardia, generalized body aches, extreme fatigue, weakness, uncontrollable twitching, tremor, and hyperreflexia. A widespread burning sensation accompanied by random hot flashes without diaphoresis was also noted. Serotonin syndrome was diagnosed using the Hunters criteria. Paroxetine was discontinued, and the patient's physical symptoms resolved within a week.

 

DISCUSSION:

 

To date, only 5 cases of serotonin syndrome have been reported in patients receiving SSRI monotherapy at recommended therapeutic doses.

[[tr...]]

It's rare for serotonin syndrome. Its just a case study and not you.

[[La...]]

It's rare for serotonin syndrome. Its just a case study and not you.

 

Of course it's not me! It's a case study. It shows what can happen, even if it's rare. The same could be said of people like us, i.e. those experiencing long-term effects from benzodiazepines. Rarely, though, are our stories reflected in medical journals as either case studies or other types of studies. If such cases are documented, then they are validated.

 

Suffice to say, I'm glad there are such case studies published. The information needs to be documented and shared.

[[Fo...]]

2004 stats for USA

1800 cases

104 death attributable to serotonin syndrome.

 

And yes I had it. -(. 

Uggg

Dick

[[La...]]

Thanks, Dick. Case studies are obviously important to report. I'd like to see some benzodiazepine withdrawal case studies -- and long-term follow-up studies that might reflect what percentage of people suffer ongoing issues.

 

As far as SSRIs go, I didn't have serotonin syndrome, but I had a number of other terrible side effects. I wasn't warned about those side effects either, and if I had been, I wouldn't have taken those meds. Total regret.

[[Fo...]]

I wish coroners would publish the suicide rate in anxiety or WD of benzos.

My impression and police forensic bod was that so many  were impulse driven in a period of anguish.

[[La...]]

They don't even blame benzos if a person falls, breaks a hip and then dies from pneumonia because they're bedridden. The benzo was the cause of the fall and fracture, but pneumonia will be listed as the cause of death. Information lost. No accountability.