Study, Apr/19: Effect of SSRIs on markers of bone loss

[[La...]]

https://www.ncbi.nlm.nih.gov/pubmed/31003023 

 

Abstract

 

Several preclinical and clinical studies show that selective serotonin reuptake inhibitors (SSRI's) are associated with bone loss and an increase in fracture risk, not many reports on their effect on bone turnover markers. This cross-sectional study evaluated the effect of SSRIs treatment on bone turnover markers in Indian population for the first time. Inclusion criteria were subjects of either sex and age 18-45 years undergoing treatment with an SSRI for at least 3 months, regardless of the indication. The results were compared with age-matched healthy controls. A total of 141 subjects were screened out of which 85 were enrolled, 44 in treatment and 41 in the control group. Serum Procollagen Type 1 Amino Terminal Propeptide (P1NP) levels were decreased in patients on SSRI treatment whereas no change was observed in the beta-C-terminal telopeptide (β-CTX) and receptor activator of nuclear factor kappa-Β ligand (RANKL) levels suggesting that these drugs can reduce bone formation but not resorption. Patients on SSRI treatment also showed reduced pCREB levels indicating that reduced bone formation is possibly through the gut mediated pathway. Our study suggests that SSRIs treatment at therapeutic doses may have a deteriorating effect on bone requiring caution in patients with additional risk factors.

[[Ma...]]

I KNEW it!!!!!

 

ANd I took all of them

 

I am 37 years old, and I fear new fractures every day. How can they bring such meds on the market.  :'( :'(

[[La...]]

I know, Marigold. I should never have been on them either. These risks have been known for awhile, and there's no excuse not to warn people about them BEFORE they take such medications.

[[Ma...]]

I know, Marigold. I should never have been on them either. These risks have been known for awhile, and there's no excuse not to warn people about them BEFORE they take such medications.

 

here comes a hug for you:

[[La...]]

Hey, thanks, Marigold! I'll send one back to you. We don't have manatees here in Ontario, but I'll send you a bear hug. We do have bears! Or how about a squirrel hug? Or a raccoon hug? We have lots of raccoons. I'll also send some deer hugs, and a few coyote hugs as well. Why not? I'm on a roll.

 

[[Ma...]]

Hey, thanks, Marigold! I'll send one back to you. We don't have manatees here in Ontario, but I'll send you a bear hug. We do have bears! Or how about a squirrel hug? Or a raccoon hug? We have lots of raccoons. I'll also send some deer hugs, and a few coyote hugs as well. Why not? I'm on a roll.

 

 

I can need all animal hugs I can get

Tomorrow is my big bone density versus new fracture appointment in the hospital with that MRI and so on.. I hope I can do that ..

[[La...]]

Ooh, I'm sending more hugs then, and a huge wish that it all goes easily and well for you, Marigold! You can do it!