what does kindled mean?

[[in...]]

sorry if somebody already started the topic but what does kindled exactly mean? going on and off? if yes means that days or really months?

 

 

[Guest [ba...]]

Kindling is simply defined as multiple reinstatements of a medication.

[[Re...]]

"Kindling due to substance withdrawal refers to the neurological condition which results from repeated withdrawal episodes from sedative–hypnotic drugs such as alcohol and benzodiazepines. Each withdrawal leads to more severe withdrawal symptoms than the previous withdrawal syndrome. Individuals who have had more withdrawal episodes are at an increased risk of very severe withdrawal symptoms, up to and including seizures, and death. Withdrawal from GABAergic-acting sedative–hypnotic drugs causes acute GABA underactivity as well as glutamate overactivity, which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity, and increasingly profound neuroadaptions."

[[in...]]

thank you!