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Study, May/17: "A review of sleep disorders and melatonin"


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Neurological Research: 2017 May 1:1-7. doi: 10.1080/01616412.2017.1315864. [Epub ahead of print]

A review of sleep disorders and melatonin.

Xie Z1, Chen F1, Li WA2, Geng X3, Li C1, Meng X1, Feng Y1, Liu W1, Yu F1.

Author information

 

1

    a Department of Neurology , Beijing Haidian Hospital , Beijing , China.

2

    b Department of Neurological Surgery , Wayne State University School of Medicine , Detroit , MI , USA.

3

    c Department of Neurology , Beijing Luhe Hospital Capital Medical University , Beijing , China.

 

Abstract

 

Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis and cause significant impairments in social and occupational functions. Although currently approved medications are efficacious, they are far from satisfactory. Benzodiazepines, antidepressants, antihistamines and anxiolytics have the potential for dependence and addiction. Moreover, some of these medications can gradually impair cognition. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone produced by the pineal gland and released exclusively at night. Exogenous melatonin supplementation is well tolerated and has no obvious short- or long-term adverse effects. Melatonin has been shown to synchronize the circadian rhythms, and improve the onset, duration and quality of sleep. It is centrally involved in anti-oxidation, circadian rhythmicity maintenance, sleep regulation and neuronal survival. This narrative review aims to provide a comprehensive overview of various therapeutic functions of melatonin in insomnia, sleep-related breathing disorders, hypersomnolence, circadian rhythm sleep-wake disorders and parasomnias. Melatonin offers an alternative treatment to the currently available pharmaceutical therapies for sleep disorders with significantly less side effects.

 

 

Click on the link below to see the above abstract and to get access to the full paper. The link is in the upper right-hand corner, where it says, "View Full Text".

 

https://www.ncbi.nlm.nih.gov/pubmed/28460563 

 

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