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Of course it can! Whenever you have change in your life - not necessarily a bad change; even a good change can be uncomfortable initially - that feeling of discomfort and anxiety can A. cause cortisol release, which is similar (albeit milder in comparison) to taking oral hydrocortisone, and B. can cause a glutamate surge, and your body doesn't have the appropriate machinery in withdrawal needed to counterbalance that glutamate surge.
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