Study, Dec./16: "Antidepressants and gabapentinoids in neuropathic pain..."

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The full title of this study is "Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights".

 

From the study:

 

"Antidepressant drugs are not acute analgesics but require a chronic treatment to relieve neuropathic pain, which suggests the recruitment of secondary downstream mechanisms as well as long-term molecular and neuronal plasticity."

 

"Gabapentinoids, which target the voltage-dependent calcium channels α2δ-1 subunit, inhibit calcium currents, thus decreasing the excitatory transmitter release and spinal sensitization."

 

https://www.ncbi.nlm.nih.gov/pubmed/27401055