ssris increase seratonin AND Glutimate?

[[Wi...]]

http://time.com/3636985/antidepressants-depression/

 

Am on my phone so can't post the actual artic

cal but this seems to suggest that ssris not only increase serotonin but also glutimate.  It eould make sense as to why the are too activating/stimulating for many of us.  Would be nice if doctors perhaps knew this too?

[[bu...]]

I think most docs do know this.  The initial stimulant/anxiety effect of SSRIs has been pretty well established and published.

 

Both my GP and my pdoc cautioned me that I might experience this with an SSRI.  Actually, my first dose of Zoloft caused such a severe reaction, my GP advised me to avoid all SSRIs.

[[Wi...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

[[th...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

 

The thing is anything involving an excitatory response will implicate glutamate. If it wakes you up, jacks you up, or increases anxiety, it will involve glutamate, even if it's an indirect involvement. That's why stress and stims can really rev us up, because any excitation will cause a ramping up of glutamate.

[[Wi...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

 

The thing is anything involving an excitatory response will implicate glutamate. If it wakes you up, jacks you up, or increases anxiety, it will involve glutamate, even if it's an indirect involvement. That's why stress and stims can really rev us up, because any excitation will cause a ramping up of glutamate.

I'm aware glutimates actions, again, what suprises me is it's involvement in SSRIs. 

[[th...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

 

The thing is anything involving an excitatory response will implicate glutamate. If it wakes you up, jacks you up, or increases anxiety, it will involve glutamate, even if it's an indirect involvement. That's why stress and stims can really rev us up, because any excitation will cause a ramping up of glutamate.

I'm aware glutimates actions, again, what suprises me is it's involvement in SSRIs.

 

That's the thing though, is anything that is excitatory implicates glutamate. And I do mean anything and everything. SSRIs, coffee, a punch in the face, slamming your fingers in the car door, getting mad at your kid when they bring home a bad grade from school, sugar, and so on and so forth. Anything and everything.

[[...]]

yeah, i can relate... a few weeks ago i went back on an SSRI... in my nervous system's sensitive state, i had an intense anxiety starting those antidepressants for the first few days... i had gone on SSRIs many times before, never having that "stimulating" effect...

 

that being said, that anxiety eventually went away after a few days and its been worth it imo

[[Wi...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

 

The thing is anything involving an excitatory response will implicate glutamate. If it wakes you up, jacks you up, or increases anxiety, it will involve glutamate, even if it's an indirect involvement. That's why stress and stims can really rev us up, because any excitation will cause a ramping up of glutamate.

I'm aware glutimates actions, again, what suprises me is it's involvement in SSRIs.

 

That's the thing though, is anything that is excitatory implicates glutamate. And I do mean anything and everything. SSRIs, coffee, a punch in the face, slamming your fingers in the car door, getting mad at your kid when they bring home a bad grade from school, sugar, and so on and so forth. Anything and everything.

My point is that SSRI's are also used as antianxiety agents and it seems counterintuitive that they are intended to be excitatory.  Coffee, yes, a punch in the face yes, but to my knowledge SSRI's were never intended to emulate amphetimines.  If they were, then my bad.

[[Co...]]

Some ssri activate gaba-b receptors.

[[th...]]

I think I'm just surprised it's the action of glutamate.  Either I forgot that I had heard that or I've never specifically heard that glutamate was a significant player. I had been on Zoloft for many years, many years ago, prior to getting off benzos.  Very early in my taper when I was not very knowledgable and I was seeking relief, a p-doc prescribed Prozac.  I lasted one day. 

 

You always hear that SSRI's can be too stimulating in benzo w/d, Now I get at least part of why.

 

The thing is anything involving an excitatory response will implicate glutamate. If it wakes you up, jacks you up, or increases anxiety, it will involve glutamate, even if it's an indirect involvement. That's why stress and stims can really rev us up, because any excitation will cause a ramping up of glutamate.

I'm aware glutimates actions, again, what suprises me is it's involvement in SSRIs.

 

That's the thing though, is anything that is excitatory implicates glutamate. And I do mean anything and everything. SSRIs, coffee, a punch in the face, slamming your fingers in the car door, getting mad at your kid when they bring home a bad grade from school, sugar, and so on and so forth. Anything and everything.

My point is that SSRI's are also used as antianxiety agents and it seems counterintuitive that they are intended to be excitatory.  Coffee, yes, a punch in the face yes, but to my knowledge SSRI's were never intended to emulate amphetimines.  If they were, then my bad.

 

First a note: I'm not trying to be snarky or rude or anything. If I'm coming off that way, I do apologize. My intent is just to agree with the article you found.

 

With that said, you're often told when starting an SSRI (especially for anxiety) that your anxiety will almost certainly get worse. Or if you don't have anxiety in the first place, you may experience it initially as a side effect of the SSRI. This will usually go away as your serotonin levels slowly build up.

 

The thing is, SSRIs are stimulating medications. Whereas mood stabilizers are anti-manic medications, SSRIs are the opposite. They're "mania inducing" (okay, maybe not mania in a normal or depressed person) medications. That's why bipolar patients should either not be treated with them or be treated very cautiously with them, because they have the potential to throw bipolar patients into a full blow manic episode.

[[...]]

I believe not all SSRIs will have this effect though, as some are used to treat anxiety disorders: I'm (unfortunately) also on Escitalopram and Venlafaxine...! 

[[We...]]

Sounds like those researchers are grasping for straws. 'May' 'Might' 'Could'. Not exactly confident words. SSRI's work on serotonin re-uptake. Glutamate doesn't pop up in 99.99% of research on the class of drugs. Don't know how you came across this 1 article. I don't buy it.

 

The link to the study doesn't show up either.

[[th...]]

I believe not all SSRIs will have this effect though, as some are used to treat anxiety disorders: I'm (unfortunately) also on Escitalopram and Venlafaxine...! 

 

Well the thing is, the effect is only initial and in most people very temporary and short in duration. Many people don't notice it at all.

 

Plus we have to remember that A. SSRIs are not first and foremost stimulants, and B. they are not hard stimulants like amphetamines or cocaine, so the stim effect may not even be noticeable.

[[...]]

I believe not all SSRIs will have this effect though, as some are used to treat anxiety disorders: I'm (unfortunately) also on Escitalopram and Venlafaxine...! 

 

Well the thing is, the effect is only initial and in most people very temporary and short in duration. Many people don't notice it at all.

 

Plus we have to remember that A. SSRIs are not first and foremost stimulants, and B. they are not hard stimulants like amphetamines or cocaine, so the stim effect may not even be noticeable.

 

True!! 

[[Wi...]]

I believe not all SSRIs will have this effect though, as some are used to treat anxiety disorders: I'm (unfortunately) also on Escitalopram and Venlafaxine...! 

 

Well the thing is, the effect is only initial and in most people very temporary and short in duration. Many people don't notice it at all.

 

Plus we have to remember that A. SSRIs are not first and foremost stimulants, and B. they are not hard stimulants like amphetamines or cocaine, so the stim e5ffect may not even be noticeable.

Which is why it made no sense to me that you would automatically make a general assignment of ssris to have the same stimulant properties as the experience as getting punched  in the face or like others that you mentioned. 

 

And yes i do think you meant to come off snarky and you were successful

[[th...]]

Which is why it made no sense to me that you would automatically make a general assignment of ssris to have the same stimulant properties as the experience as getting punched  in the face or like others that you mentioned. 

 

And yes i do think you meant to come off snarky and you were successful

 

WWwI,

 

Again, I'm sorry that I sound like I'm coming off snarky. I genuinely did not intend that.

 

I've put in my 2¢ and said I agreed with the article you found, as well as given my reasoning for my agreement. That's what I came here to do, and I've done it, so now I'm done with this thread.

 

I wish you the best in your healing.

[[Co...]]

When I started taking paxil I was irritable and tired for about 5 days then it went away. That was way before benzos though.